How long does it take for nicotine to not show in blood or urine?

The amount of time that nicotine stays in the system and show up in blood or urine varies based on a number of factors. Lifestyle, body weight and smoking rate affect the amount of time nicotine will remain in the blood or urine, according to HealthGuideHQ.com.

For an average smoker, the amount of time the chemical substances from nicotine remain in the bloodstream is two weeks, states HealthGuideHQ.com. More long-term and frequent smokers could have nicotine traceable in their system for one to three months. Testing options vary, and each has different time frames on tracing the use of nicotine.