What are some side effects of deglycyrrhizinated licorice?

While deglycyrrhizinated licorice is safe and may be effective for some conditions in moderate amounts, long-term consumption in medicinal concentrations can lead to side effects such as high blood pressure, low potassium levels, weakness and paralysis, according to MedlinePlus. On rare occasions, overuse of licorice can result in brain damage.

Women may experience missed menstrual periods, and men may have reduced interest in sex as a result of consuming high concentrations of licorice, states MedlinePlus. Licorice may also cause tiredness, headaches, and water and sodium retention.

Especially at risk for the harmful effects of licorice are individuals with high blood pressure, heart disease, hypertonia and low potassium levels, notes MedlinePlus. Women who are pregnant or nursing and individuals preparing for surgery also should avoid licorice supplements.