Can Tylenol and Advil be mixed?

Tylenol and Advil can be taken together, according to the Mayo Clinic. However, the Mayo Clinic advises people to avoid using these two medications together for more than a few days, unless directed to do so by a doctor.

Tylenol contains a common type of painkiller called acetaminophen, according to WebMD. Advil contains ibuprofen, which is a non-steroidal anti-inflammatory drug (NSAID), according to MedlinePlus. MedlinePlus explains that NSAIDs can have serious side effects, including gastro-intestinal bleeding, so it is important that patients avoiding exceeding the recommended dose. According to MedlinePlus and WebMD, because Tylenol and Advil can interact with a wide range of other medications, patients who are taking other medications should ask a doctor or pharmacist for advice before using either drug.