What is the most effective treatment for melasma?

The most effective melasma treatments include 2-percent, over-the-counter, hydroquinone cream and 4-percent, prescription-strength, hydroquinone cream, states MedlinePlus. To enhance skin lightening, physicians prescribe tretinoin and a corticosteroid to be used in tandem, or a 'triple cream' containing all three types of medication, explains the American Academy of Dermatology.

In some instances, melasma clears up on its own, without over-the-counter or prescription medications, through the use of sunscreen or the avoidance of UV rays altogether, explains MedicineNet.com. In instances where the discoloration is triggered by pregnancy or birth control, the skin disorder can fade after birth or when birth control and hormone therapy are discontinued.