How long does Advil stay in your system?

Advil has a half-life of 1.8 to 2 hours when taken orally, which means it is out of the system by the 4-hour mark. The only ingredient in Advil is ibuprofen, a non-steroidal anti-inflammatory drug.

Advil is often used for the treatment of pain or inflammation caused by toothaches, headaches, arthritis, back pain, menstrual cramps, fever and minor injuries. The use of Advil is not recommended after heart bypass surgery and may cause life-threatening circulation problems when used for extended periods of time, according to Drugs.com. Advil is available in capsule and tablet forms for oral use and in suspension form for children's use.