Is it possible to pass a drug test using niacin?

No scientific evidence supports the use of niacin to pass drug tests, and users who attempt to use niacin in this manner may have adverse reactions, according to the Centers for Disease Control and Prevention. Adverse reactions reported include skin flushing, itching, dizziness and vomiting.

Those who attempt to circumvent drug tests with niacin operate under the misapprehension that niacinamide, which is chemically similar to niacin, removes toxins from their systems. Laboratory drug tests can identify compounds in the patient sample that are commonly rumored to aid in passing a drug test, and labs can report that information to the party that commissioned the test, notes the CDC.