What prescription medications work best for sinus blockage?

Antibiotics are generally the most effective medications for resolving sinus blockages due to sinusitis, according to American Family Physician. Medications such as systemic decongestants and nasally-administered steroids tend to have little beneficial effect for most patients.

Though antibiotics are effective in the treatment of blocked sinuses due to bacterial infection, these drugs have little to no beneficial effects for patients with sinusitis arising from viral infections or allergic reactions, as reported by WebMD. It is often difficult for doctors to distinguish the cause of sinusitis in a particular case, so many patients with sinusitis are prescribed antibiotics even though they cannot benefit from their effects.