What are the most serious neuropathy symptoms?

Depending on the type of nerve affected, neuropathy can cause symptoms such as muscle weakness or paralysis, sensitivity to touch, sharp pain, loss of coordination and numbness and tingling in the hands and feet, states Mayo Clinic. Other symptoms include blood pressure changes, heat intolerance and bladder or bowel problems.

A loss of feeling can allow sores and blisters to develop unnoticed on a patient's feet, according to eMedicineHealth. Because the patient is unable to feel pain, the sores can become infected and spread to deeper layers of tissue, including bone. Severe infections may require amputation of the affected foot.