Does spironolactone cause weight gain?

Weight gain is not a known side effect of spironolactone. Some side effects include gastric bleeding, ulceration, gastritis, vomiting, diarrhea, abdominal cramping, gynecomastia, hematologic side effects, hypersensitivity and hyperkalemia, explains Drugs.com.

Spironolactone is prescribed for the treatment of primary hyperaldosteronism, congestive heart failure with edema, liver cirrhosis accompanied by edema, nephrotic syndrome with edema, essential hypertension, hypokalemia, and severe heart failure, according to Drugs.com. Because spironolactone raises potassium levels, patients taking the drug must be careful when eating food rich in potassium or when taking potassium supplements to avoid developing hyperkalemia. The drug is also contraindicated in patients with anuria, acute renal insufficiency, renal excretory dysfunction and hyperkalemia.